Optimising HFO&VTV in Newborn Infants

Launched by KING'S COLLEGE HOSPITAL NHS TRUST · Dec 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to support breathing in newborn infants who need help with their lungs. It focuses on a method called High Frequency Oscillation with Volume Targeted Ventilation (HFO&VTV), which is designed to deliver air to the lungs in a way that minimizes lung injury and helps control levels of carbon dioxide in the blood. The researchers want to see if this method is safer for infants compared to standard High Frequency Oscillation (HFO) and how it affects blood flow to the brain and heart function. They will also explore what the best starting amount of air to deliver is for different babies.

The trial is open to newborn infants, regardless of their age at birth, who are receiving high frequency oscillatory ventilation. However, infants with certain brain or heart conditions will not be included. If a baby participates, they will be monitored while receiving different amounts of air for short periods, and simple ultrasound tests will be done to check their brain and heart health afterward. This study is important because it aims to improve the care of newborns who require breathing support.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Newborn infants of any gestation receiving high frequency oscillatory ventilation
• Exclusion Criteria:
• • Infants with known intracerebral pathology (stroke, hydrocephalus, intracerebral hemorrhage, severe hypoxic ischemic encephalopathy).
• • Infants with congenital cardiac abnormalities.