Probiotics Combined with Enteral Nutrition Reduces Postoperative Infectious Complications in PD

Launched by THE AFFILIATED NANJING DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL · Dec 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how probiotics, which are beneficial bacteria, combined with special nutrition given through a feeding tube (called enteral nutrition), can help reduce infections after a specific type of surgery known as pancreaticoduodenal surgery. The goal is to see if this combination can help patients recover more smoothly and avoid complications related to infections after their surgery.

To participate in this trial, you need to be an adult over 18 years old and scheduled for elective pancreaticoduodenal surgery, meaning it's planned in advance rather than done in an emergency. It's important that you understand the study and can give your consent to take part. However, if you have recently used probiotic products or antibiotics, or if you have certain health conditions that make the surgery high-risk, you won't be eligible. If you decide to join, you can expect to receive either the probiotics and enteral nutrition or standard care, and your recovery will be closely monitored to see how well you do after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients greater than 18 years of age;
• • Indication for elective pancreaticoduodenal surgery;
• • Patients who understand the nature of the trial and are willing and able to provide written consent
• Exclusion Criteria:
• • . Current or recent (within the previous 1 month) use of probiotic-based products or antibiotic therapy medications.
• • Inability to tolerate PD due to cardiopulmonary function and other parameters
• • Received radiotherapy before surgery
• • Emergency PD surgery
• • Pregnant and breastfeeding women