The Collagen Factors of Rapid Progression of Keratoconus in Children.

Launched by ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY · Dec 3, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at keratoconus, a condition that affects the shape of the cornea (the clear front part of the eye) and can cause vision problems. The goal is to learn more about how keratoconus differs between children and adults, especially focusing on Chinese children. The researchers want to see how the cells in the cornea behave in children with this condition and to understand what causes keratoconus to progress quickly in younger patients.

To participate in the study, you need to be between 10 and 50 years old and have been diagnosed with keratoconus. You should also be willing to attend follow-up appointments and understand what the study involves. However, people who have worn contact lenses recently, have had certain eye surgeries, or have other serious eye problems won’t be eligible. If you join, you can expect to undergo some eye examinations and tests to help the researchers gather important information about keratoconus in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ① Patients with keratoconus who visit the refractive clinic.
• • 1. The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography.
• • 2. ARTAve \< 424 microns, ARTMax \< 339 microns.
• • 3. Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism.
• • Aged between 10 and 50 years old, no gender restrictions.
• • Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form.
• Exclusion Criteria:
• • ① There is a history of contact lens wearing in the last four weeks.
• • poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery).
• • History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc..
• • ⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium.
• • ⑥ Any systemic disease affecting eye morphology and refractive interstitium.