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Search / Trial NCT06725095

Effects of Enamel Matrix Derivative in the Treatment of Peri-implant Mucositis

Launched by UNIVERSITY OF CATANIA · Dec 5, 2024

Trial Information

Current as of June 26, 2025

Enrolling by invitation

Keywords

Enamel Matrix Derivative

ClinConnect Summary

Patients (n° 54) with Implants affected by PM were randomly assigned to test (NSMD+EMD) or control procedures (NSMD + placebo). At baseline, 1, 3, 6 months, full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depth (PD), bleeding on probing (BOP), modified gingival index (mGI), and modified plaque index (mPlI) will assessed as well as levels of periodontal bacteria such as Aggregatibacter Actynomycencomitans, Porphyromonas Gingivalis, Tannerella Forsythia and Treponema Denticola. The BOP reduction was set as a primary outcome and the patient was considered statistical ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • age ≥18 years old;
  • implants with smooth necks supporting cemented or screw-retained single-unit crowns with at least one BOP-positive site (Berglundh et al., 2018),
  • implants placed in both maxilla and mandible
  • patients with gingivitis or treated periodontitis with the absence of residual PD ≥5 mm
  • presence at least of 2 mm of keratinized mucosa (KT) at implant sites
  • Exclusion Criteria:
  • presence of systemic diseases;
  • pregnancy or lactating;
  • use of inflammatory drugs or antibiotics within 3 months prior to study recruitment;
  • implants with modified (i.e., micro-rough) necks;
  • interproximal open contacts between implant restoration and adjacent teeth; peri-implantitis (Berglundh et al., 2018)

About University Of Catania

The University of Catania, a distinguished institution in Italy, is committed to advancing medical research and improving patient care through innovative clinical trials. With a rich history of academic excellence and a multidisciplinary approach, the university collaborates with healthcare professionals and researchers to explore new therapeutic interventions and enhance existing treatment protocols. By leveraging its state-of-the-art facilities and a robust network of clinical partnerships, the University of Catania aims to contribute significantly to the field of medicine and address pressing health challenges through rigorous scientific inquiry and ethical research practices.

Locations

Catania, Ct, Italy

Patients applied

0 patients applied

Trial Officials

Gaetano Isola, DDS

Principal Investigator

University of Catania

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported