Evaluation of a Novel Microbiological Diagnostic Test for Latent Mycobacterium Tuberculosis Infection

Launched by QUEEN MARY UNIVERSITY OF LONDON · Dec 10, 2024

Keywords

ClinConnect Summary

Objectives:

i) To determine whether M. tuberculosis (Mtb) DNA can be detected in CD34+ peripheral blood mononuclear cells (PBMC) isolated from

* asymptomatic adults being screened for LTBI (LTBI screenees)
* adults with newly-diagnosed active tuberculosis (active cases) ii) To determine whether strains of Mtb isolated from CD34+ PBMC of recent household TB contacts are genetically identical to those isolated from the sputum of index cases with pulmonary TB to whom they have been exposed iii) To characterise immunological, clinical and epidemiological correlates of ability to detect Mtb in...

Gender

ALL

Eligibility criteria

• • i) For LTBI screenees
• Inclusion Criteria:
• • Age ≥16 years
• • Undergoing screening for LTBI
• • Gives written informed consent to participate
• Exclusion Criteria:
• • Known HIV infection
• • Declines HIV testing
• • Previous antimicrobial treatment for active TB or latent TB infection
• • Clinical suspicion of active TB
• • Already initiated chemoprophylaxis
• • ii) For adults with active TB Inclusion criteria
• • Age ≥16 years
• • Newly-diagnosed active TB about to initiate treatment
• • Gives written informed consent to participate
• • Exclusion criteria
• • Known HIV infection
• • Declines HIV testing
• • Already initiated anti-TB treatment
• • Haemoglobin concentration \<10 g/dl at screening