Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Dec 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called soquelitinib to see if it can help reduce the number of immune cells in people with Autoimmune Lymphoproliferative Syndrome (ALPS), a rare immune system disorder. ALPS causes the body to produce too many lymphocytes, which can lead to swollen lymph nodes and spleen. The trial aims to find a better treatment option that has fewer side effects than current therapies.

To participate, individuals must be at least 16 years old and have a confirmed diagnosis of ALPS with signs of active disease, such as swollen lymph nodes or spleen. Participants will visit the clinic for exams, blood tests, and scans over the course of a year, and they will take soquelitinib as a tablet twice daily. They'll keep track of their medication and any symptoms they experience. This study is currently recruiting participants, and some may have the opportunity to remain in the study for a second year.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• To be eligible to participate in this study, an individual must meet all the following criteria:
• • 1. Aged \>= 16 years.
• • 2. Able to provide informed consent (for ages \>= 18 years) or has a parent(s) or guardian(s) who can provide permission to participate on their behalf (for ages \<18 years).
• • 3. Has a documented diagnosis of ALPS-FAS.
• • 4. Has clinical evidence of active disease, defined as at least one enlarged lymph node and/or enlarged spleen.
• • 5. If currently on corticosteroid therapy, then dose is less than 20 mg/day (prednisone equivalent) and has been stable for at least 4 weeks.
• • 6. For participants to be seen at the NIH CC, co-enrolled on NIH protocol 93-I-0063.
• 7. Participants who can become pregnant or who can impregnate their partner must agree to either remain sexually abstinent or use two highly effective methods of contraception when engaging in sexual activities that can result in pregnancy, beginning 28 days before baseline until 3 months after the last dose. One method must be a barrier (eg, internal or external condom, cervical cap, or diaphragm). The second method may be any of the following:
• • 7a. Oral contraceptive pill or hormonal patch or ring.
• • 7b. Parenteral hormonal contraceptive implant.
• • 7c. Intrauterine device.
• EXCLUSION CRITERIA:
• An individual who meets any of the following criteria will be excluded from participation in this study:
• • 1. Profound grade 3 or 4 cytopenias that cannot be improved with immunomodulatory treatments prior to enrolling in the clinical trial and starting the study drug. Per investigator discretion, individuals on a single agent may be included if the dose is stable for 12 weeks at screening and is not expected to confer additive toxicity.
• • 2. Renal impairment, defined as serum creatinine \>1.5 mg/dL (or 133 micromol/L) or estimated glomerular filtration rate \<60 mL/min/1.73 m\^2.
• • 3. Liver impairment, defined as bilirubin, alanine aminotransferase, or aspartate aminotransferase greater than 2.5 times the upper limit of normal.
• • 4. History of EBV-associated lymphoma.
• • 5. Active EBV infection with EBV load \>300 copies/mL.
• • 6. Tuberculosis infection (active or latent) or undergoing tuberculosis treatment.
• • 7. Infection with HIV or hepatitis B or C.
• • 8. Current other invasive or systemic fungal, bacterial, or viral infection requiring therapy.
• • 9. History of opportunistic infection within the previous 180 days.
• • 10. History of invasive malignancy that required systemic therapy within the last 3 years.
• • 11. Current use of moderate or strong cytochrome P450 isozyme (CYP)3A inhibitors or inducers that cannot be stopped before day 0.
• • 12. Current use of P-glycoprotein (P-gp) inhibitors that cannot be stopped before day 0.
• • 13. Known hypersensitivity or contraindication to CT contrast agent.
• • 14. Pregnant or breastfeeding.
• • 15. Any condition that, in the opinion of the study team contraindicates participation in this study.