Image-Based Prediction of Ventricular Tachycardia Events in Non-ischemic Cardiomyopathy

Launched by CENTRO MEDICO TEKNON · Dec 8, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to predict serious heart rhythm problems, known as ventricular tachycardia (VT), in patients with non-ischemic cardiomyopathy (NICM). NICM is a condition that affects the heart muscle but is not caused by blocked arteries. The study aims to use advanced imaging techniques to measure specific heart tissue characteristics that could help identify patients at higher risk for these dangerous heart events. This information could lead to better management strategies and potentially save lives.

To participate in the trial, individuals must have a diagnosis of NICM, such as dilated cardiomyopathy, and should not have had any previous serious heart rhythm issues. Participants need to be in relatively good health and have a life expectancy of more than one year. They will undergo non-invasive heart imaging using a technique called late gadolinium enhancement cardiac magnetic resonance (LGE-CMR), which helps visualize heart tissue. Throughout the study, researchers will follow these patients to see if the identified heart tissue characteristics can accurately predict the occurrence of VT events.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Diagnosis of non-ischemic heart disease involving the left ventricle, irrespectively of LVEF. This diagnosis includes:
• • 1. Dilated cardiomyopathy (DCM)
• • 2. Non-dilated left ventricular cardiomyopathy (NDLVC)
• • 3. Post-myocarditis cardiomyopathy
• • Life expectancy of \> 1 year with a good functional status.
• • Signed informed consent.
• • At least one late gadolinium enhancement-cardiac magnetic resonance (LGE-CMR) already performed.
• • No VA events at the time of the 1st LGE-CMR study.
• Exclusion Criteria:
• • Pregnancy.
• • Life expectancy of \< 1 year, or bad functional status (NYHA IV functional class).
• • Other concomitant structural heart diseases (e.g. ischemic, congenital, arrhythmogenic right ventricular cardiomyopathy etc.)
• • No LGE-CMR at time of enrollment or LGE-CMR data not available.
• • Previously documented sustained ventricular arrhythmias at the time of 1st LGE-CMR.
• • Concomitant investigation treatments.
• • Medical, geographical and social factors that make study participation impractical, and inability to give written informed consent. Patient's refusal to participate in the study.