Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery

Launched by ALLEGHENY SINGER RESEARCH INSTITUTE (ALSO KNOWN AS ALLEGHENY HEALTH NETWORK RESEARCH INSTITUTE) · Dec 9, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well different methods of managing pain work for patients undergoing minimally invasive surgery for various types of cancer. The study will compare three pain management techniques: one that includes a local anesthetic injection, another that uses the same injection technique but without the anesthetic, and a third that uses only local anesthetic. If you choose to participate, you'll be assigned to one of these methods at random, similar to flipping a coin. The research team will monitor your pain levels, medication usage, any side effects, and your overall satisfaction with pain control during your hospital stay.

To be eligible for this trial, you need to be between 18 and 89 years old and scheduled for elective surgery related to specific cancers. You should be in good health (classified as ASA I, II, or III) and able to communicate about your pain. Participation is voluntary, and the study will involve standard care before and after surgery, with data collected for the first 24 hours and at discharge. It's important to note that certain conditions, like chronic pain disorders or severe health issues, may exclude you from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female patients age ≥ 18 - 89
• • 2. Patients scheduled for elective (clinically indicated) hepatic, gastric, biliary, pancreatic, gynecologic, colorectal, other GI Minimally invasive oncologic surgery.
• • 3. Patients who have provided informed consent to participate in the study.
• • 4. Patients with an American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.
• • 5. Patients undergoing procedures anticipated to last more than 1 hour but less than 8 hours.
• • 6. Patients able to understand and self-report pain using the designated pain Visual Analog Scale
• Exclusion Criteria:
• • 1. Patients age less than 18 or ≥ 90
• • 2. Pre-existing hepatic dysfunction, cirrhosis
• • 3. Patients with an ASA classification of IV or higher.
• • 4. Patients with chronic pain disorders or on long-term opioid or analgesic therapy.
• • 5. Patients with known contraindications to the study drugs or procedures (e.g., allergy to LA or contraindications to LapTAP).
• • 6. Patients with cognitive impairments or psychiatric conditions that could interfere with pain assessment or understanding of informed consent.
• • 7. Patients unable to understand the language in which consent and study-related information are provided (The study and the study-related information will be in the English Language)..
• • 8. Patients who have undergone major surgery within the last 6 months.
• • 9. Female patients who are pregnant.
• • 10. Patients currently enrolled in another clinical trial that might interfere with the outcome measures of this study.