The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS

Launched by VIETNAM MILITARY MEDICAL UNIVERSITY · Dec 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to improve lung function in patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition that makes it hard to breathe. The researchers want to see if using a special imaging tool called Electrical Impedance Tomography (EIT) can help doctors choose the best settings for a type of breathing support called Positive End-Expiratory Pressure (PEEP). This study will compare the effectiveness of EIT-guided PEEP settings to the usual method, which uses standard tables, to find out which approach better helps patients improve their oxygen levels and lung mechanics.

To participate in this trial, individuals must be at least 18 years old and currently require mechanical ventilation due to moderate to severe ARDS, meaning their blood oxygen levels are significantly low. Participants will be closely monitored while receiving this tailored breathing support. It’s important to note that certain conditions, such as having a recent chest injury or being pregnant, may exclude someone from joining the trial. This research could lead to better treatment strategies for ARDS, potentially improving outcomes for many patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years.
• • Intubated moderate and severe ARDS according to the New Global Definition (PaO2/FiO2 ≤200 mmHg).
• • Used continuous sedation with or without paralysis.
• Exclusion Criteria:
• • Presence of pneumothorax that is either undrained or newly occurred.
• • Unstable hemodynamics with a mean arterial pressure \< 60 mmHg and unresponsive to resuscitation measures, and/or heart rate \< 60 bpm.
• • Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application).
• • Pregnancy.
• • Severe neuromuscular disease.