Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis

Launched by NECMETTIN ERBAKAN UNIVERSITY · Dec 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying certain substances in saliva called biomarkers—specifically asprosin, IL-39, IL-40, and IL-1β—to see how they relate to diabetes and gum disease, known as periodontitis. The researchers want to find out if these biomarkers differ between people with and without diabetes, and between those with periodontitis and those who have healthy gums. The goal is to see if these biomarkers can help diagnose gum disease early or track its progress over time.

To participate in this study, individuals must be between the ages of 18 and 65 and should not have certain health conditions like serious kidney or heart problems. They should also have at least 20 teeth and should not have received recent dental treatments or antibiotics. The study is currently not recruiting participants, but if someone is eligible, they can expect to provide saliva samples and undergo dental examinations to assess their gum health. This research could provide valuable insights into the connection between diabetes and gum disease, which is important for developing better care strategies.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:- No systemic disease such as nephrotic syndrome, chronic renal disease and cardiovascular disease
• • No dental scaling and root planing treatment in the last 6 months
• • No antibiotic use for any reason
• • Having at least 20 teeth in the mouth
• • Not being pregnant or breastfeeding
• • Inclusion criteria for the periodontally healthy group
• • Having a periodontally healthy diagnosis in routine clinical and radiographic examinations Inclusion criteria for the periodontitis group
• • Diagnosing periodontitis in routine clinical and radiographic examinations
• Exclusion Criteria:
• • - Patients with any autoimmune disease (Rheumatoid arthritis, familial Mediterranean fever, ankylosing spondylitis, Behcet, psoriasis, etc.) - Those who smoke 10 or more cigarettes per day