Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Dec 11, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how exercising on a stationary bike before hemodialysis (a treatment for kidney failure) might help protect the heart. Researchers want to find out if this pre-dialysis exercise can reduce a temporary condition called "heart stunning," which is when the heart doesn't pump as strongly during the dialysis session. The study will also check if exercising beforehand can lessen common symptoms that patients experience during hemodialysis.

To be eligible for this trial, participants must be at least 18 years old and have been on hemodialysis for at least three months. They should be cleared by their doctor to exercise and must be able to give informed consent. However, people who regularly engage in vigorous exercise outside of their dialysis sessions, those over 79 years old, or individuals with certain heart conditions may not qualify. If you join the study, you can expect to cycle before your dialysis treatment and help researchers understand how exercise might benefit heart health during this important process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • must be on chronic hemodialysis for at least 3 months
• • age 18 years or older
• • willing and able to provide informed consent
• • assessed to be safe and able to exercise by unit HD Nephrologist
• Exclusion Criteria:
• • regular vigorous exercise outside of hemodialysis
• • over 79 years of age
• • intradialytic exercise \< 3 months
• • poor echogenicity
• • acute coronary syndrome in the past 3 months
• • unstable arrhythmia/angina
• • shortness of breath at rest or with minimal activity
• • symptomatic hypoglycemia (\>2x/week in the week prior to enrolment)