Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation

Launched by KAROLINSKA INSTITUTET · Dec 13, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how a special heart imaging technique, called cardiac magnetic resonance (CMR), can help detect problems in patients with a rare heart condition known as univentricular heart (UVH). This condition affects how the heart pumps blood and can lead to serious issues like heart failure. The researchers want to see if they can spot early signs of heart problems and microvascular dysfunction—issues in the tiny blood vessels—before patients show any symptoms. By doing so, they hope to start treatment sooner, which could lead to better health and fewer hospital visits for these patients.

To participate in the study, individuals must be over 18 years old and have had a specific heart surgery called total cavo-pulmonary connection (TCPC) that results in Fontan circulation. They should also be in classes I or II of the New York Heart Association's classification, meaning they have mild symptoms. Unfortunately, those with more severe heart issues, certain heart devices, kidney failure, or who are pregnant cannot take part in the trial. Participants can expect to undergo advanced heart imaging procedures that are safe and do not involve radiation, helping to provide valuable information about their heart health. Overall, this study aims to improve care for young adults with this complex heart condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who had undergone total cavo-pulmonary connection (TCPC) surgery resulting in Fontan circulation.
• • NYHA (New York Heart Assosiation) class I-II.
• • Understanding the study information (signed informed consent).
• • \>18 years old.
• Exclusion Criteria:
• • Device therapy (pacemaker, ICD).
• • Failing Fontan (NYHA III-IV).
• • Kidney failure (GFR\<30ml/h).
• • Arrythmia (atrial fibrillation).
• • Pregnancy.