Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Dec 13, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how a Ketogenic Diet (KD) can help people who have lost weight maintain their weight loss. Specifically, the researchers want to see if this type of diet can increase the number of calories your body uses (called Total Energy Expenditure or TEE) and improve feelings of hunger. The study will involve individuals aged 18 to 65 with a body mass index (BMI) between 30 and 45, which means they are classified as obese. To participate, individuals should be relatively inactive, meaning they exercise less than 2 hours a week.

If you meet these criteria and decide to join, you can expect to follow a specific diet while the researchers monitor your energy use and appetite. It’s important to note that certain conditions or factors, like pregnancy, significant recent weight changes, and specific health issues, may prevent someone from participating in this trial. This study is not yet recruiting participants, but it aims to provide valuable insights into effective weight loss maintenance strategies.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI 30-45 kg/m2
• • Both men and women
• • Age between 18-65 years
• • Sedentary to moderately active (\<2 h/wk of moderate, structured, intentional, exercise)
• Exclusion Criteria:
• • Pregnancy or lactation
• • Daily use of tobacco (\>1 pk/wk)
• • Change in weight greater than 5 lb in the previous 3 months
• • Cognitive impairment
• • Previous bariatric surgery
• • History of eating disorder
• • Presence of any condition (e.g. DM2, PCOS, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis)
• • Use of any medication (e.g., glucocorticoid, GLP-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes.
• • Pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives
• • Fasting glucose plasma concentration \>125 mg/dl and/or HbA1c \> 6.4%