The Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis Patients

Launched by QIANFOSHAN HOSPITAL · Dec 12, 2024

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ClinConnect Summary

This clinical trial is investigating how managing potassium levels can help protect the heart in patients with chronic kidney disease who are on hemodialysis, a treatment that cleans the blood when the kidneys are not working properly. Patients often experience fluctuations in potassium levels during and after dialysis, which can lead to serious heart problems. The study will use a medication called sodium zirconium cyclosilicate to help control high potassium levels before dialysis and adjust the potassium in the dialysate (the fluid used during dialysis) to reduce the risk of low potassium after the treatment. The goal is to see if stabilizing potassium levels can lower heart injury in these patients.

To participate in this trial, you need to be between 18 and 75 years old, have been on hemodialysis for at least three months, and have potassium levels that are high but not dangerously so (between 5.0 and 8.0 mmol/L) before dialysis. You'll also need to be able to manage your daily activities independently. If you have certain heart conditions, severe health issues, or other specific problems, you may not be eligible. If you join the trial, you can expect close monitoring and support as researchers evaluate how this treatment affects your heart health over time.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18-75 years old;
• • 2. Maintenance hemodialysis ≥3 months;
• • 3. Serum potassium ≥5.0mmol/L and ≤8mmol/L before dialysis;
• • 4. Have independent ability;
• • 5. Complete clinical baseline data.
• Exclusion Criteria:
• • 1. Complicated with congenital heart disease, myocardial infarction and other heart diseases that may lead to cardiac dysfunction;
• • 2. Combined with other serious diseases, such as immune diseases, severe liver and kidney dysfunction;
• • 3. Unable to cooperate with the researcher due to mental reasons;
• • 4. If the duration of dialysis is less than 4 hours, severe infection;
• • 5. Patients with malignant tumors or major mental disorders;
• • 6, except primary cardiomyopathy;
• • 7. Severe constipation, intestinal obstruction, etc.
• • 8. other investigators considered that enrollment was not recommended.