The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults

Launched by UNIVERSITY OF BRITISH COLUMBIA · Dec 11, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a 48-hour fast, with or without exercise, on the immune system and blood sugar control in healthy, active adults. Many people fast for health reasons, but we don't fully understand how it affects the body's immune cells and overall metabolism. This study aims to find out how fasting impacts the body's immune functions and how it helps manage glucose levels, which is important for energy and overall health.

To participate in this study, you need to be between 19 and 35 years old and regularly engage in physical activity, like exercising for at least 150 minutes each week. However, certain individuals are not eligible, such as those with specific health conditions, those on special diets like ketogenic diets, or those who smoke. If you decide to join, you'll experience a two-day fasting period, and you'll have the option to incorporate exercise during that time. This study could provide valuable insights into how fasting and exercise work together for your health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged between 19 and 35 years.
• • Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).
• Exclusion Criteria:
• • History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).
• • Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).
• • Cigarette/vaping smoking.
• • Physical limitation that will impair the ability of the participant to perform exercise.
• • Individuals having a body mass index (BMI) over 30 kg/m2.
• • Cancer diagnosis in the past 5 years.
• • Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).
• • Being unable to read or communicate in English.