The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Approach

Launched by ARMY MEDICAL UNIVERSITY, CHINA · Dec 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for a procedure called adrenal vein sampling, which helps diagnose a condition known as Primary Aldosteronism (PA). PA is a condition where the body produces too much of a hormone called aldosterone, often leading to high blood pressure and other serious health issues. The trial aims to compare the effectiveness and safety of using a single catheter (a thin tube) versus two catheters to collect samples from the adrenal glands through veins in the arm. By finding the best method, researchers hope to make the diagnosis process easier and more affordable for patients with PA.

To be eligible for this trial, participants need to be between 18 and 70 years old and have high blood pressure that shows signs of PA, which will be determined through specific tests. People who are pregnant, have certain severe health issues, or have allergies to specific contrast agents will not be able to participate. Those who join the trial can expect to undergo the sampling procedure and contribute to important research that could improve the way PA is diagnosed and treated in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18-70 years with hypertension.
• • Initial screening shows a standing aldosterone/renin ratio (ARR) \> 3.7, a baseline aldosterone level \> 10 ng/dl, aldosterone level \> 6 ng/dl after a saline load test, or aldosterone decrease of less than 30% after a captopril suppression test, consistent with a diagnosis of primary aldosteronism.
• • Voluntary participation in the trial, with signed informed consent.
• Exclusion Criteria:
• • Patients with an allergy to iodinated contrast agents.
• • Patients who are pregnant, breastfeeding, or planning to become pregnant.
• • Patients with severe comorbidities, such as renal failure, liver cirrhosis, metastatic tumors, or those who have had an acute stroke or acute myocardial infarction, as well as patients with a history of surgery within the past month.
• • Patients suspected of having adrenal cortical carcinoma.

Trial Officials