Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Dec 16, 2024

Keywords

ClinConnect Summary

This clinical trial is designed to study how the body reacts to inflammation in different types of arthritis, including rheumatoid arthritis, osteoarthritis, and spondyloarthritis. The researchers want to learn more about the changes that happen in the tissues of the joints of patients with these conditions. By understanding these changes, they hope to improve treatment options for individuals suffering from arthritis.

To participate in this study, you need to be over 18 years old and have been diagnosed with arthritis in one or more joints. However, if you have certain health conditions, such as a history of bleeding problems or allergies to local anesthetics, you may not be eligible. Although the trial is not currently recruiting participants, once it starts, those who join can expect to undergo tests that involve analyzing joint tissue, which may help in developing better arthritis treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>18 years
• • Clinically relevant arthritis in one or more joints as assessed by the treating rheumatologist, including RA, SpA, connective tissue disease and OA.
• Exclusion Criteria:
• • Known allergies to local anesthetics
• • Family history of bleeding, history of increased bleeding tendency or prolonged bleeding, current treatment with oral anticoagulants or platelet aggregation inhibitors; Quick \< 65%, international normalised ratio (INR) ≥ 1.3, thrombocyte count \< 100'000/μl, activated partial thromboplastin time (aPTT) \> 37 sec
• • Inability or insufficient knowledge of project language to understand the information given in the informed consent form