Clinical Efficacy of a Chlorhexidine-based Mouth-rinse Containing Citrus Aurantium Amara

Launched by UNIVERSITY OF ROMA LA SAPIENZA · Dec 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a special mouthwash that contains chlorhexidine, a common antiseptic, along with natural ingredients like citrus extract. The main goal is to see how effective this mouthwash is for helping wounds heal after dental surgery, while also checking for issues like plaque buildup and gum inflammation. Participants will be divided into two groups: one will use the new mouthwash, and the other will use a standard chlorhexidine mouthwash.

To be eligible for this study, participants should be between the ages of 65 and 74, have more than 20 natural teeth (excluding wisdom teeth), and need surgery to treat specific gum issues. Participants should not have certain health conditions, like diabetes or heart disease, and should not be pregnant or breastfeeding. If you join the trial, you will be asked to use the mouthwash as directed and attend follow-up appointments to monitor your healing and any side effects. This study is still in the planning stage and has not started recruiting participants yet.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • More than 20 natural teeth excluding the third molars
• • Clinical indication for a surgical intervention for the treatment of at least one residual pocket after non-surgical therapy (pocket depth (PD) ≥5mm)
• • Have a full mouth plaque score (FMPS) \<15% before surgery;
• • Have a full mouth bleeding score (FMBS) \<15% before surgery;
• • Ability and willingness to give written informed consent;
• • Written agreement to participate in the trial.
• Exclusion Criteria:
• • Use of medications, such as anti-platelet or anti-coagulant agents, any other concomitant systemic disorder, cardiovascular and diabetes diseases, allergic, infectious diseases and medications affecting periodontal inflammation
• • Pregnancy or breastfeeding;
• • Use of medication affecting the healing process;
• • Assumption of systemic or local antibiotics in the 4 weeks before trial beginning;
• • Conditions of the teeth or of the site that contraindicate the surgery (severe mobility, fractures, untreated endodontic lesions, incongruous restorations);
• • Patients with previous periodontal treatment or who were undergoing a course of dental or orthodontic treatment will be also excluded.
• • Tobacco use (10 or more cigarettes per day)
• • Inability to comply with protocol
• • Uncooperative patient