Enhancing Physical Function in Older Adults With Chronic Kidney Disease

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Dec 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at whether a special exercise program can help older adults with advanced chronic kidney disease (CKD) improve their physical strength and ability to move. The study will last 12 weeks and will involve a form of exercise called high-velocity resistance training (HVRT), which is designed to build muscle power. Researchers will compare this exercise program with a group that meets weekly to discuss healthy lifestyle topics, to see if the exercise helps improve physical function in participants.

To participate in this trial, individuals must be between the ages of 65 and 90, have CKD stages 4-5, and be able to do some physical exercise. They should also live within 20 miles of the Wake Forest Reynolda Campus and be able to speak English fluently. Those interested should be aware that they will be randomly assigned to either the exercise program or the discussion group. The study aims to ensure that the exercise is both safe and manageable for older adults with mobility challenges. Overall, this trial is an important step in determining if this type of exercise can benefit older adults with kidney issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chronic kidney disease stage 4-5
• • Capacity to complete physical exercise
• • Lives within 20 miles of Wake Forest Reynolda Campus
• • Fluent English speaker
• • Does not plan to travel outside of home area for an extended period of time during study
• • Willing to be randomized to either intervention group
• • Short physical performance battery score of 9 or higher
• Exclusion Criteria:
• • Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
• • Dependent on walking device
• • Current participation in a resistance training program
• • Joint replacement or orthopedic surgery in the previous 6-months or planning to have surgery in the next 6- months
• * Absolute contraindications to exercise testing according to ACSM:
• • Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection
• • Parkinson's disease
• • Respiratory disease requiring oxygen
• • Cancer requiring treatment
• • Currently receiving physical therapy or cardiopulmonary rehabilitation
• • Type I or insulin dependent Type II Diabetes
• • Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
• • Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence