Aortic Stiffness by CMR in Aortic Coarctation

Launched by ASSIUT UNIVERSITY · Dec 17, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Aortic Stiffness by CMR in Aortic Coarctation," is looking at how well blood pressure is controlled in adults who have had a procedure called coarctation stenting, which helps treat a condition where the aorta (the main artery supplying blood to the body) is narrowed. Researchers will use a special imaging technique called cardiac magnetic resonance (CMR) to measure how stiff the aorta is over time. This study aims to find out if there is a link between blood pressure control and the stiffness of the aorta in these patients.

To participate in this trial, individuals must be 14 years or older and have a specific type of aorta narrowing known as aortic coarctation. They should have a certain level of blood pressure difference and be in good overall heart function. However, some people may not be eligible, such as those with severe heart valve issues or other health conditions that could affect the results. While the trial is not yet recruiting participants, those who join can expect to undergo CMR imaging to help researchers better understand their heart health after treatment.

Gender

ALL

Eligibility criteria

• • Patient criteria Inclusion criteria All patients with native or recurrent aortic coarctation between the age of 14 years and older.
• • Transcatheter systolic gradient ≥ 20 mm Hg, body weight ≥ 20 kg, and normal LV ejection fraction (EF).
• • Exclusion criteria Patients with obstructive lesion of LVOT or aortic valve dysfunction greater than moderate (requiring surgical intervention).
• • Irregular cardiac rhythm. Patients with other causes of secondary hypertension. Contraindications to CMR: Any contraindications to undergoing CMR, such as implanted metallic devices incompatible with MRI, severe claustrophobia.
• • Unicuspid aortic valve Associated complex congenital heart defects (aside from simple septal defects and patent ductus arteriosus) Genetic syndromes Connective tissue disorder History of surgery involving the aortic root or ascending aorta.