Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide

Launched by MONTEFIORE MEDICAL CENTER · Dec 14, 2024

Keywords

ClinConnect Summary

This clinical trial is designed to compare the effectiveness of two medications, fosaprepitant and metoclopramide, for treating nausea and vomiting, particularly in patients who visit the emergency department. Fosaprepitant is a newer medication that works by blocking a specific signal in the brain that triggers vomiting. The goal of the study is to find out which medication is more effective and to see if either has more side effects. This research is important because many people experience nausea and vomiting and may benefit from a treatment that works better or is easier to get.

To participate in the trial, you must be at least 18 years old and seeking treatment for nausea or vomiting in the emergency department. However, certain individuals are not eligible, including pregnant or breastfeeding women, those who have received specific treatments before arriving at the hospital, or those with certain heart conditions. If you qualify, you can expect to receive one of the two medications and will be monitored for how well it works for you and any side effects you may experience. This study is not yet recruiting participants, but it aims to provide valuable information on better treatment options for nausea and vomiting.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults at least 18 years old
• • Present to ED for treatment of Nausea and/or vomiting as defined by the International Classification of Diseases (ICD-10) or identified by treating clinician
• Exclusion Criteria:
• • Pregnancy, desiring pregnancy, or lactating
• • Antiemetic use or intravenous fluids prior to presenting to ED for evaluation and management
• • Bradycardia (\< 60 bpm heart rate)
• • Prolonged QTc (greater than 490ms)
• • Not conversant in English or Spanish
• • Altered mental status
• • Dementia
• • Lack of phone for follow-up communication