Skeletal Muscle Index and a Neuromuscular Blocking Agent

Launched by SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL · Dec 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the amount of muscle a person has, measured from preoperative CT images, affects the dosage of a medication called rocuronium used during surgery. Rocuronium helps to relax muscles, which is important for surgeries that require general anesthesia. The researchers want to see if there is a link between a person's muscle mass and the amount of this medication needed to keep the muscles relaxed during the surgery.

To be eligible for this study, participants need to be adults scheduled for elective colon surgery and in good health, as defined by the American Society of Anesthesiologists (classes 1-3). They must also agree to participate and have a routine preoperative CT scan. However, people who are pregnant, have certain kidney problems, or take medications that influence muscle relaxation will not be included. Those who join the study can expect to have their muscle mass assessed before surgery and to help researchers understand how muscle affects medication needs in surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Those who voluntarily agreed and signed the written consent form before participating in the study
• • American Society of Anesthesiologists physical class (ASA class) 1-3
• • Patients scheduled for elective colon surgery under general anesthesia
• • Patients undergoing abdominal computed tomography for routine preoperative preparation
• Exclusion Criteria:
• • Pregnant women
• • Decreased renal function (GFR\<60mL/min/1.73m2).
• • Patients taking drugs that affect deep neuromuscular blockade
• • Patients with a history of neuromuscular and muscle disorders