The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

Launched by HEALTHY MINDS INITIATIVE · Dec 15, 2024

Keywords

ClinConnect Summary

The INSPIRE Study is a research project looking at how certain lifestyle choices can help maintain brain health and prevent dementia, particularly in African American communities that are more affected by these issues. The study will include 2,000 participants aged 55 and older who have normal cognitive abilities or some early signs of cognitive decline. By focusing on healthy habits, the researchers hope to find ways to support cognitive function and overall well-being.

To be eligible for the study, participants need to be at least 55 years old, live in the Crenshaw area of California, and be fluent in English. They should have normal thinking abilities or mild concerns about their memory. Participants will be asked to attend assessments, join in on lifestyle activities, and complete questionnaires about their health and habits. This study is not yet recruiting participants, but it aims to address important health disparities and help improve brain health in the community.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: Participants must be 55 years of age or older.
• • Ethnicity: Focused on African American individuals, but not exclusive.
• • Cognitive Status: Participants must have normal cognitive status, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI).
• • Language: Participants must be fluent in English.
• • Location: Must reside in the Crenshaw, California area or be able to attend study-related activities in this location.
• • Willingness to Participate: Participants must be willing to adhere to the study protocol, including attending assessments, participating in interventions, and completing questionnaires.
• Exclusion Criteria:
• • Cognitive Decline: Diagnosis of dementia or severe cognitive impairment that would interfere with the ability to participate in the study.
• • Physical Limitations: Any physical or medical condition that would preclude participation in the lifestyle interventions (e.g., severe mobility issues).
• • Recent Cancer Diagnosis: Diagnosis of cancer within the last three years, excluding stable cases of basal cell or squamous cell carcinoma of the skin, or stable prostate cancer.
• • Pregnancy: Current pregnancy or planning to become pregnant during the study period.
• • Mental Health: Diagnosis of severe psychiatric disorders such as schizophrenia or bipolar disorder that might interfere with participation.
• • Substance Abuse: Current substance abuse or dependency that could impact participation.
• • Hearing Impairment: Uncorrected hearing loss that would limit the ability to communicate and participate in the study.
• • Non-English Speaking: Inability to participate in English-language oral and written cognitive assessments.
• • Participation in Another Study: Currently enrolled in another clinical trial that could interfere with the INSPIRE Study.
• • Life expectancy less than 3 years
• • Unwillingness to share medical and laboratory information.