Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum

Launched by UNIVERSITY OF TORONTO · Dec 16, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to understand how our bodies respond to a liquid protein meal at different ages, for both men and women, and based on how active we are. The study aims to find out how well our bodies can use protein for building and repairing muscles, a process known as anabolic sensitivity. This information could help us learn more about healthy aging and how physical activity affects our metabolism over time.

To participate, you need to be healthy and fall within certain age ranges: either between 8 to 16 years, or 18 to 35 years, or 60 to 80 years. Participants should also have a body mass index (BMI) that is considered normal to overweight. However, there are some restrictions; for example, if you regularly use certain medications, have specific health issues, or are pregnant, you may not be eligible. If you join the study, you can expect to consume a protein drink and provide information about your diet and physical activity. This research could provide valuable insights into how different factors influence our body's ability to process protein throughout our lives.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone)
• • Chronological age for Healthy Young (age: 18-35 years) or Older (age: 60-80 years) adults
• • Chronological age between 8 to 16 years, with maturity offset \< -1 year from age of Peak Height Velocity (aPHV) for children and between -0.5 to +1.5 years from aPHV in adolescent participants
• • BMI between normal to overweight (18.5 - 29.9 kg/m2)
• Exclusion Criteria:
• • Regular use of nonsteroidal anti-inflammatory dugs (with the exception of daily low-dose aspirin)
• • use of anticoagulants
• • use of a walker, cane, or assistive walking device
• • infectious or gastrointestinal disease
• • inability to comply with study protocol (e.g., unable to track diet)
• • regular tobacco use
• • self-reported illicit drug use (e.g., growth hormone, testosterone, etc.)
• • diagnosed chronic illness (e.g., type 2 diabetes, heart disease, thyroid disease)
• • pregnant
• • hormonal replacement therapy