Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Dec 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how genetic testing can help tailor cancer treatment for children and young adults with cancer. The goal is to understand how specific gene variations can affect how patients respond to cancer medications. By analyzing multiple genes at once, researchers hope to find important information that can guide doctors in choosing the right drugs and dosages for individual patients. This can lead to more effective and safer treatments.

To be eligible for this study, participants need to be 26 years old or younger, newly diagnosed with cancer, and planning to start anti-cancer therapy or are candidates for a bone marrow transplant. They will need to provide consent (and assent if applicable) from themselves or their parents. Participants should expect to provide a sample for genetic testing, which will be used to identify any relevant gene-drug interactions that could help improve their treatment. It's important to note that this study is not yet recruiting participants, so those interested will need to wait for the recruitment phase to begin.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Written informed consent and HIPAA authorization for release of personal health information, and assent when applicable, from the participant, parent or legal guardian.
• • 2. Age ≤ 26 years at the time of consent.
• • 3. Newly diagnosed with a malignancy and planning to undergo anti-cancer therapy; or bone marrow transplant candidate with a non-malignant diagnosis who has not yet undergone myeloablative conditioning regimen.
• Exclusion Criteria:
• • 1. Anti-cancer therapy has already been initiated. Note: Enrollment after initiation of intrathecal chemotherapy will be allowed.
• • 2. Previously received bone marrow transplant or planning to receive as part of initial upfront therapy for a malignant condition.
• • 3. Prior history of tissue or organ transplant.