Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Launched by UNIVERSITY OF AARHUS · Dec 17, 2024
Trial Information
Current as of June 27, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Primary aim (baseline):
To assess the prevalence of isolated REM Sleep Behavior Disorder (iRBD) or REM sleep without atonia (RSWA) in patients with idiopathic polyneuropathy with as to without abnormal cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy (assessment of cardiac sympathetic innervation)
Secondary aim (baseline):
To assess the prevalence of Parkinson's Disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) in patients with idiopathic polyneuropathy.
Hypothesis (baseline):
iRBD is more prevalent in patients known with idiopathic polyneuropathy ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Definite polyneuropathy without known etiology (idiopathic) AND orthostatic hypotension (active stand test) OR non-nocturnal blood pressure reduction (24 hour blood pressure measurement)
- Exclusion Criteria:
- • Known etiology of polyneuropathy
- • A diagnosis of either dementia, Parkinson's disease, Dementia with Lewy Bodies or Multiple System Atrophy.
About University Of Aarhus
The University of Aarhus, a prestigious research institution located in Denmark, is dedicated to advancing medical science through innovative clinical trials. With a strong emphasis on interdisciplinary collaboration, the university fosters an environment that encourages cutting-edge research and the development of novel therapeutic interventions. Committed to ethical standards and patient safety, the University of Aarhus aims to contribute to the global body of medical knowledge while enhancing healthcare outcomes through rigorous scientific inquiry and evidence-based practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Aarhus, Jutland, Denmark
Patients applied
Trial Officials
Astrid J. Terkelsen, MD, DrMedSc, PhD, Professor
Principal Investigator
Department of clinical medicine, Aarhus University and Department of Neurology, Aarhus University Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported