Effect of Different Inspired Oxygen Concentrations on Intraoperative Recruitment Outcomes in Patients Undergoing Abdominal Surgery

Launched by NORTHERN JIANGSU PEOPLE'S HOSPITAL · Dec 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different amounts of oxygen breathed in during abdominal surgery can help improve lung function. The researchers want to find out the best level of oxygen to use that will help open up the small air sacs in the lungs, making it easier for patients to breathe after surgery. They will monitor changes in lung performance during the operation to see which oxygen concentration works best.

To be eligible for this study, participants must be adults aged 18 to 64 years, have a healthy weight, and be scheduled for elective abdominal surgery lasting at least 1.5 hours. They should not have any serious lung or heart diseases, nor have had certain previous surgeries. If someone joins the trial, they will give their consent after understanding the study, and they can expect to be monitored closely during their surgery to see how their lungs respond to the different oxygen levels.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA physical status classification: I or II.
• • Adults aged 18 to 64 years, regardless of gender.
• • BMI between 18 kg/m² and 25 kg/m².
• • Patients undergoing elective abdominal surgery under general anesthesia.
• • Patients with estimated operating time ≥1.5h and intraoperative bleeding ≤500ml.
• • Patients who have provided written informed consent after understanding the study purpose, procedures, and potential risks.
• Exclusion Criteria:
• • Previous thoracic surgery.
• • Chest X-ray or CT suggestive of pneumothorax or alveoli.
• • Lung disease: chronic bronchitis, asthma, moderate to severe obstructive ventilatory dysfunction.
• • Preoperative pulse oxygen saturation (SpO2) \<90% on breathing air or SpO2 \<95% on oxygen.
• • Contraindications to lung reanimation: high intracranial pressure, hypovolemic shock, right heart failure.
• • Severe heart disease (New York Heart Association, NYHA class III or IV.
• • Acute coronary syndrome or sustained ventricular tachyarrhythmia).
• • Participation in other interventional studies or refusal of enrollment.