The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study

Launched by CHIANG MAI UNIVERSITY · Dec 19, 2024

Keywords

ClinConnect Summary

Hemorrhoidal disease, characterized by symptomatic enlargement and distal displacement of anal cushions, has been a subject of recognition and management for centuries. The etymology of "hemorrhoid" is traced back to the Greek words haima (blood) and rhoos (flow). Prevalent in over 20% of the population across various life stages, this anorectal condition impacts both genders. The multifaceted development of the disease incorporates theories encompassing abnormal dilation of hemorrhoidal plexuses, distension of arteriovenous anastomoses, prolapse of anal pads, and a myriad of genetic, anato...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute active bleeding hemorrhoid grade 1 and 2 with in 7 days
• • Age over 20 years
• • In patients aged over 50 years, it is imperative to confirm the absence of any alternative causes of bleeding through a colonoscopy
• • Can follow up in 6 months
• Exclusion Criteria:
• • Bleeding disorder
• • History of colorectal cancer, inflammatory bowel disease, portal hypertension, chronic kidney disease grade 3 or over
• • Patient required other treatment such as hemorrhoidectomy or RBL
• • Patient who received antiplatelet or anticoagulant
• • Physical exam reveals anal fissure
• • Pregnancy
• • Any psychotic disorder
• • Refuse to participate