Optic Nerve Injury in Obstructive Sleep Apnea Patients

Launched by NANJING MEDICAL UNIVERSITY · Dec 19, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the connection between obstructive sleep apnea (OSA) and a condition called ischemic optic neuropathy (ION), which can cause damage to the optic nerve. OSA is a sleep disorder where breathing repeatedly stops and starts, leading to low oxygen levels during sleep and resulting in daytime tiredness. The study aims to understand how OSA may affect blood flow to the optic nerve, which is important because the current understanding of this relationship is not clear. The trial will include 80 patients diagnosed with OSA, who will be divided into groups based on the severity of their condition.

To be eligible for the study, participants must be between 18 and 80 years old and have been newly diagnosed with OSA. They should not have had any previous treatments or surgeries for their sleep apnea. If you join the trial, you can expect to undergo several tests to assess your sleep and eye health at the beginning and again after a 3-month treatment period using a CPAP machine, which helps keep the airways open while sleeping. This research could provide valuable insights into how treating sleep apnea might help protect vision, so your participation could contribute to important findings in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged between 18 and 80 years.
• • 2. Diagnosed with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)(apnea-hypopnea index≥5/h).
• • 3. First-time diagnosis, with no previous surgical interventions or CPAP treatment for OSA.
• • 4. Ability and willingness to provide informed consent for participation in the study.
• Exclusion Criteria:
• • 1. History of severe stroke or cerebral hemorrhage, or presence of neurological or psychiatric conditions that could affect study results.
• • 2. Presence of active malignancies or other severe underlying diseases, such as severe liver or kidney dysfunction. Diagnosed with diabetes or other significant vascular diseases.
• • 3. Presence of severe chronic obstructive pulmonary disease (COPD), severe asthma, severe pulmonary hypertension, or heart failure caused by any condition.
• • 4. Pregnancy or having other conditions that make participation in this study unsuitable.
• • 5. Extremely debilitated patients or those with severe underlying conditions.