Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Dec 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a simpler way to test for primary aldosteronism, a condition that can cause high blood pressure and low potassium levels. The researchers want to find out if a 2-day oral sodium loading test can give results that are just as reliable as the traditional 3-day test. This test involves taking a special diet that includes sodium to help measure the amount of aldosterone, a hormone, in urine over 24 hours.

To participate in this trial, you need to be between 20 and 70 years old, have been diagnosed with primary aldosteronism, and have certain health measurements, like a specific body mass index (BMI) and blood pressure range. Healthy volunteers are also welcome, as long as they meet similar age and health criteria. Participants can expect to undergo dietary changes and provide urine samples during the study. This research aims to make the testing process easier, which could help more people get the diagnosis they need.

Gender

ALL

Eligibility criteria

• PA patients:
• Inclusion criteria:
• • Patients with hypertension and hypokalemia who have been diagnosed with primary aldosteronism following the latest version international guidelines for primary aldosteronism.
• • Age: 20-70 years old, male and female;
• • BMI: 18.5-23.9 kg/m2;
• Exclusion criteria:
• • Other causes of endocrine hypertension including pheochromocytoma, Cushing syndrome, etc.
• • Renal artery stenosis and low potassium due to other factors, such as renal tubular acidosis, Bartter syndrome, Gitelman syndrome, etc.
• • History of hyperthyroidism, hepatic and renal insufficiency, malignant tumors, metabolic diseases, cardiovascular diseases, and mental diseases,menstrual disorders Healthy volunteers
• Inclusion criteria:
• • Age: 20-70 years old, male and female;
• • BMI: 18.5-23.9 kg/m2;
• • Blood pressure: 90-120/60-80 mmHg on three consecutive office blood pressure readings;
• • Female must have regular menstrual cycle (blood and urine samples should be taken during the non-menstrual period);
• • Regular dietary habits;
• • No medications taken within the past 1 month.
• Exclusion criteria:
• • History of hypokalemia.
• • History of liver and kidney dysfunction, malignant tumors, metabolic disorders, cardiovascular diseases, and psychiatric disorders, etc.
• • Menstrual irregularities and taking contraceptive pills.
• • History of hypertension
• • Have taken any drugs including anti-inflammatory drugs, potassium diuretics, or special health products in the 4 weeks prior to the examination,