Effect of Low Tidal Volume Ventilation on Postoperative Delirium

Launched by NEVSEHIR PUBLIC HOSPITAL · Dec 27, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how a specific type of breathing support, called low tidal volume (LTV) ventilation, may help reduce the risk of postoperative delirium in patients undergoing heart surgery. Postoperative delirium is a condition where patients become confused and disoriented after surgery, which can complicate their recovery. The researchers believe that using LTV during surgery could improve blood flow and oxygen delivery to the brain, potentially lowering the chances of delirium. They will compare two groups of patients: those receiving LTV and those receiving a different breathing method. The study will track how many patients experience delirium, how long they stay in the intensive care unit (ICU), and any health complications within 30 days after surgery.

To participate in this trial, individuals must be at least 18 years old and scheduled for planned heart surgeries, such as coronary artery bypass grafting (CABG). However, patients with certain conditions, like emergency surgeries, severe mental health issues, or those taking specific medications, will not be eligible. If you decide to take part in the study, you can expect to be monitored closely for signs of delirium and other health outcomes, helping researchers learn more about how breathing techniques during surgery can impact recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All male or female patients over the age of 18
• • Patients undergoing planned cardiac surgeries including CABG
• • Patients with an American Society of Anesthesiologists (ASA) physical status of II, III, or IV
• Exclusion Criteria:
• • Emergency surgeries will be excluded due to the high likelihood of non-compliance with the protocol and the potential lack of essential patient information.
• • Surgeries requiring single-lung ventilation will be excluded as they may cause confusion in determining any effects of the intervention due to the inability to apply the study intervention and the differential treatment of the lungs.
• • Patients who meet delirium criteria according to 3D-CAM measurements during the initial visit will be excluded.
• • Patients with a life expectancy of less than 6 months or a history of psychiatric or neurological diseases (including depression, severe central nervous system depression, schizophrenia, epilepsy, Parkinson's disease, and Alzheimer's disease) will be excluded.
• • Severe impairments such as blindness, severe deafness, or dementia that may hinder cognitive testing will be excluded.
• • Patients using psychotropic or opioid medications, those with a history of delirium, or those with a history of alcohol abuse or withdrawal within the past 6 months will be excluded.