rTMS Combined With Motor Training for the Treatment of Upper Limb Motor Dysfunction in Stroke Patients

Launched by RUIJIN HOSPITAL · Dec 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called repetitive transcranial magnetic stimulation (rTMS) to help stroke patients regain movement in their arms. The goal is to see if this treatment, which uses magnetic fields to stimulate the brain, can improve rehabilitation for patients who have difficulty moving their arms after a stroke. Researchers will compare how well rTMS works with different types of motor training against other methods that do not involve rTMS. They want to find out if this individualized online approach can help patients recover better, whether they can produce certain brain signals called motor evoked potentials (MEPs) or not.

To be eligible for the trial, participants should be between 18 and 80 years old, have recently had a stroke, and still have some arm movement difficulties. They should also be able to understand and participate in assessments. Throughout the trial, participants will receive rTMS treatment over two weeks, undergo brain scans and tests before and after treatment, and complete assessments at various points to measure their progress. This trial is currently recruiting participants, so if you or someone you know fits the criteria and is interested, it could be a great opportunity to contribute to understanding new rehabilitation methods for stroke recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The patient is first diagnosed with stroke through neurological examination, CT or MRI scan.
• • 2. The vital signs are stable and there is a certain degree of upper limb motor dysfunction.
• • 3. The age is between 20 and 80 years old.
• • 4. The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points.
• • 5. There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition).
• • 6. There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures).
• • 7. The patient or guardian agrees to sign the informed consent form.
• Exclusion Criteria:
• • 1. Patients with severe heart, lung, liver, kidney diseases and malignant tumors;
• • 2. Those with a history of aphasia, severe cognitive impairment or mental illness;
• • 3. Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently;
• • 4. Those with severe visual or hearing impairments, unable to communicate normally;
• • 5. People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS.