Hormonal Control of Energy and Macronutrient Intake in Obesity (MEMORY)

Launched by STENO DIABETES CENTER COPENHAGEN · Dec 20, 2024

Keywords

ClinConnect Summary

The MEMORY study is looking at how our bodies remember the food we eat and how different types of nutrients (like fats, proteins, and carbohydrates) affect what we want to eat later. Researchers want to see if this "food memory" works differently for people with different body weights, from those with normal weight to those who are overweight or obese. The study is currently recruiting participants aged 18 to 45 years who have a body mass index (BMI) between 18.5 and 39.9. Women who are eligible must have regular menstrual cycles.

If you decide to participate, you'll be asked to eat specific test meals, and your responses to these meals will be monitored. However, there are certain conditions that may prevent you from joining, such as allergies, pregnancy, or certain medical issues. It's important to note that this study aims to help understand eating behaviors better, which could lead to improved treatments for obesity in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-45 years
• • For women: Regular menstruation
• • BMI-range 18.5-39.9 kg/m\^2
• Exclusion Criteria:
• • Not able or willing to eat or drink the test meals because of e.g., allergy or intolerance
• • Daily smoking
• • For women: Pregnancy / planned pregnancy (within the study period) / lactating
• • Self-reported history of an eating disorder
• • Self-reported weight change (kg) within two months prior to inclusion
• • HbA1c ≥48 mmol/mol
• • Treatment with antidepressants
• • Alcohol/drug abuse or in treatment with disulfiram (antabus) at time of inclusion
• • Uncontrolled medical issues including but not limited to cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, gastrointestinal, or psychiatric disease; diabetes or other endocrine disease; immunosuppression
• • Current treatment with medication which significantly affect appetite or energy balance (e.g., GLP-1 receptor agonists)
• • Bariatric surgery
• • Unable to understand the informed consent and the study procedures
• • Concomitant participation in intervention studies
• • Participant's withdrawal of the informed consent
• • Other safety concerns - judged by the investigator