Cryoablation of Brain Neoplasm

Launched by ERASMUS MEDICAL CENTER · Dec 22, 2024

Keywords

ClinConnect Summary

Cryoablation is a therapeutic modality that employs extreme cold to induce cell necrosis in tumor tissue. While the application of cryoablation for the treatment of brain tumors remains under investigation, it has been extensively utilized in other organ systems with outcomes often surpassing those of conventional therapies.

The primary objective of this research is to evaluate the safety and feasibility of cryoablation as a treatment option for patients diagnosed with various brain tumors, including gliomas, meningiomas, and metastatic lesions. Participants enrolled in this study will fir...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>18 years
• • Tumor suspected as glioma (1. Astrocytoma, IDH mutant 2. Oligodendroglioma, IDH-mutant and 1p/19q-codeleted 3. Glioblastoma, IDH-wildtype), meningioma (WHO gr. 1 and gr 2), or brain metastasis based on preliminary diagnosis for which the patient will undergo surgery
• • Supratentorial or infratentorial localization
• • Safe trajectory/trajectories possible for ablation of at least 70% of the tumor, avoiding eloquent structures
• • Karnofsky performance scale 70 or more
• • Sufficient knowledge of the Dutch language to understand the study documents (in the judgement of the attending physician or researcher)
• • Written Informed consent
• Exclusion Criteria:
• • \<18 years or \>80 years
• • Tumor diameter bigger than 10 cm
• • Unsafe trajectory (eloquent structures could be damaged)
• • Pregnancy
• • Contra-indication for general anesthesia