Healthy Plant-based Diet and Periodontal Treatment

Launched by THE UNIVERSITY OF HONG KONG · Dec 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a healthy plant-based diet in combination with non-surgical periodontal treatment on patients with periodontitis, a serious gum disease. The aim is to see if this dietary change can improve the health of the gums and overall immune response in patients, without causing any nutritional issues. Researchers are looking for participants aged 18 to 64 who are of Chinese ethnicity and have been diagnosed with Stage II or Stage III periodontitis. Ideal candidates should be in good general health, have a body mass index (BMI) between 18.5 and 28, and currently eat less than the recommended amounts of fruits and vegetables.

Participants in the trial will be randomly assigned to two groups: one will follow a healthy plant-based diet under the guidance of a registered dietitian, while the other group will continue their usual eating habits without any dietary changes. Throughout the study, participants will receive regular periodontal treatment and check-ups over a year to monitor their progress. This research aims to provide valuable insights into how diet can influence gum disease treatment and potentially improve health outcomes for those affected by periodontitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chinese ethnicity aged between 18 and 64;
• • Generalized Stage II and Stage III periodontitis;
• • at least 10 occluding pairs present;
• • Good general health;
• • Never-smoker or former smoker who had quit smoking successfully for at least 12 months prior to the screening visit;
• • Body mass index (BMI) ranging between 18.5 and 28 kg/m2;
• • Self-reported inadequacy of hPBD with the main focus on fresh vegetables (\<300 g/day) or/and fruit (\<200 g/day) with reference to the Dietary Guidelines for Chinese residents (Society, 2022).
• Exclusion Criteria:
• • Edentulism
• • Presence of any systemic disease or taking medication that can alter the manifestation/outcome of periodontal treatment (e.g., uncontrolled diabetes mellitus, hypertension with use of calcium channel blocker, etc.)
• • Pregnancy or intention to become pregnant at any point during the study duration
• • Need for antibiotic prophylaxis in the context of dental treatment
• • Having received non-steroidal anti-inflammatory medication or antibiotics within the previous 3 months
• • Having received professional periodontal treatment (other than supragingival cleaning) within the previous 12 months
• • History or clinical manifestation of any eating disorder as determined the International Classification of Diseases
• • Presence of any dietary restriction (e.g., adherence to a Mediterranean diet), currently taking nutrient supplements or inability to choose his/her diet
• • Having obvious weight change (≥5% of current body weight) over the past 6 months
• • Participation in another intervention trial
• • Inability or unwillingness of individual to give written informed consent