Evaluation of Blood Protein O-GlcNAcylation Levels in Children

Launched by NANTES UNIVERSITY HOSPITAL · Dec 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the levels of a specific blood protein called O-GlcNAcylation in children who are experiencing sepsis or septic shock, as well as in healthy children. Researchers believe that stimulating this protein may help improve heart function and survival in cases of severe infections. While this approach has shown promise in animal studies, it has not yet been tested in humans. The goal of this trial is to understand if it can be beneficial for children facing serious health challenges.

Children aged 0 to 17 years can participate, whether they are healthy or have suspected or confirmed sepsis. Healthy children must be visiting the hospital for routine blood tests, while those with sepsis will be involved if they show signs of infection. Parents or guardians will need to give their consent for their child to join the study. Participants can expect to provide a blood sample, and the researchers will monitor the outcomes to see if this treatment helps improve their condition. It's important to note that children with certain medical conditions, such as immune deficiencies or genetic diseases, will not be eligible for this trial.

Gender

ALL

Eligibility criteria

• • 1. Healthy group
• Inclusion Criteria :
• • Age from 0 to 17 years at the time of sampling (including premature infants)
• • Children coming to hospital for a blood sample to be taken as part of a pre-operative check-up, an allergy check-up or a check-up as part of a pathology other than sepsis.
• • Premature infants benefiting from a blood sample as part of their monitoring and management of prematurity
• • Collection of umbilical cord blood
• • Signed consent
• Exclusion Criteria :
• • Children with an infection
• • Children with fever
• • Children with an immune deficiency
• • Children with autoimmune disease
• • Children with metabolic disease
• • Children with haematological diseases
• • Children with a genetic disease
• • Unsigned consent
• • Refusal by parents or child
• • 2. Septic group
• Inclusion Criteria :
• • Age from 0 to 17 years at the time of sampling (including preterm infants)
• • Children with suspected sepsis or diagnosed sepsis according to the 2016 definition
• • Premature infants having blood drawn for suspected or diagnosed sepsis
• • All responsible bacteria, viruses or fungi
• • Signed bio-collection consent
• Exclusion Criteria :
• • Children with an immune deficiency
• • Children with autoimmune disease
• • Children with a metabolic disease
• • Children with haematological diseases
• • Children with a genetic disease
• • Unsigned bio-collection consent
• • Refusal by parents or child