Imaging of Intracranial and Extracranial Arterial Atherosclerotic Plaques Using Different Field Strength MRIs

Launched by SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE'S HOSPITAL · Dec 31, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring a new imaging technique using a special type of MRI to better understand a condition called atherosclerosis, which is a buildup of plaques in the arteries that can lead to strokes. The study aims to compare the effectiveness of a newer, ultra-high field 5.0T MRI with a standard 3.0T MRI in capturing detailed images of both intracranial (inside the skull) and extracranial (outside the skull) arteries. By using this advanced imaging technology, researchers hope to get clearer pictures of the vascular walls and the characteristics of the plaques, which could help in assessing the risk of stroke.

To participate in this trial, individuals must be at least 18 years old and have moderate to severe narrowing of the arteries due to atherosclerosis, confirmed by previous imaging tests. They should not have certain conditions that could affect the MRI results or pose safety risks, such as having a pacemaker or severe allergies to MRI contrast agents. Participants will undergo advanced MRI scans, and those who qualify will help advance the understanding of atherosclerosis, potentially leading to better diagnosis and treatment options in the future. If you or a loved one is interested in learning more about this trial, please consult your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years;
• • Moderate to severe intracranial or extracranial arterial stenosis (stenosis degree: 50% to 99%, confirmed by CTA, MRA, or DSA);
• • Written informed consent signed by the patient or their legal representative.
• Exclusion Criteria:
• • Non-atherosclerotic intracranial arterial stenosis, such as dissection or moyamoya disease;
• • Contraindications to MRI, such as claustrophobia or presence of a cardiac pacemaker;
• • Allergy to gadolinium-based contrast agents;
• • Poor MRI image quality preventing analysis;
• • Abnormal liver or kidney function;
• • History of any prior endovascular treatment;
• • Presence of implants posing potential safety risks in 5.0T MRI, such as non-removable metallic dental prostheses, stents, or other metallic implants.