Research on the Relationship Between Scoliosis, Pain, Quality of Life, and Trunk Muscle Compensation Patterns Among Patients with Duchenne Muscular Dystrophy.

Launched by SEOUL NATIONAL UNIVERSITY HOSPITAL · Dec 24, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how trunk muscle movements in patients with Duchenne Muscular Dystrophy (DMD) relate to scoliosis (curvature of the spine), pain, and overall quality of life. By using advanced computer technology, researchers aim to measure how these muscle movements help patients perform daily activities and how they change over time. Participants will undergo several assessments, including X-rays to check for scoliosis and tests to evaluate their upper limb function and pain levels.

To be eligible for this study, participants must be between 10 and 30 years old, have a confirmed diagnosis of DMD, and meet specific muscle strength criteria. Healthy individuals can also participate as a comparison group if they have no muscle or nerve disorders. Those who join the study can expect to perform various tasks while their muscle activity is measured, helping researchers understand how muscle compensation affects their daily lives. This research hopes to improve care and quality of life for individuals living with DMD.

Gender

ALL

Eligibility criteria

• • 1. Inclusion Criteria (1) Duchenne Muscular Dystrophy (DMD) Group
• • Individuals with a confirmed genetic diagnosis of Duchenne Muscular Dystrophy.
• • Aged over 10 years but under 30 years.
• • Brooke Scale score between 2 and 5.
• • Shoulder abductor muscle strength below grade 3 on the Manual Muscle Test (MMT).
• • (2) Healthy Control Group
• • Individuals with no history or current diagnosis of musculoskeletal or neuromuscular disorders.
• • Aged over 10 years but under 30 years.
• • Shoulder muscle strength of grade 4+ or higher on the Manual Muscle Test (MMT).
• • Individuals capable of understanding a detailed explanation of the study procedures and voluntarily providing written informed consent.
• • 2. Exclusion Criteria (1) Duchenne Muscular Dystrophy (DMD) Group
• • Individuals unable or unwilling to provide informed consent.
• • Brooke Scale score of 1 or 6.
• • Severe cognitive impairment preventing the performance of simple tasks. (2) Healthy Control Group
• • Individuals unable or unwilling to provide informed consent.
• • Shoulder muscle strength of grade 4 or lower on the Manual Muscle Test (MMT).