Garlic Oil As Root Filling Material in Primary Molars
Launched by CAIRO UNIVERSITY · Dec 25, 2024
Trial Information
Current as of July 21, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is researching a new way to treat toothaches in young children caused by a serious condition called irreversible pulpitis, which means the nerve in the tooth is damaged. The study is testing a mixture of garlic oil and zinc oxide as a filling material for root canals in primary molars (the back teeth) of children aged 4 to 8 years. Researchers want to see if this garlic oil mixture works as well as the standard filling material, known as metapex, by comparing the success of both treatments.
To participate in this trial, children must have specific dental issues, such as a diagnosed tooth infection or damage to the tooth nerve, and certain signs like swelling or bleeding. However, children with more severe tooth problems or those whose teeth are too loose to treat will not be included. If eligible, participants can expect to receive either the garlic oil mixture or the standard treatment, and researchers will monitor their recovery and the effectiveness of the filling material. This study is still in the planning stages and has not started recruiting participants yet.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Primary second molars which are diagnosed with irreversible pulpitis, or pulp necrosis.
- • 2. Presence of sinus tract.
- • 3. Periapical bone swelling.
- • 4. Continuous bleeding after amputation of the coronal pulp tissue.
- • 5. No pulp tissue remains when the pulp chamber is accessed.
- • 6. Pus discharges from the canal.
- • 7. Radiographically, only primary molars with at least two-thirds of the root length.
- • 8. Presence of inter-radicular or periapical radiolucency.
- Exclusion Criteria:
- • 1. A tooth with internal root resorption will not be included. 2. Excessive tooth mobility beyond healing. 3. Carious perforation in the pulpal flour. 4. A tooth with a pathological lesion extending to the successor's tooth germ. 5. Non-restorable primary molars.
- • -
About Cairo University
Cairo University, a premier institution in Egypt, is dedicated to advancing medical research and education through innovative clinical trials. With a strong emphasis on improving healthcare outcomes, the university collaborates with various stakeholders to conduct rigorous scientific studies that address critical health challenges. Leveraging its extensive resources and expert faculty, Cairo University aims to contribute valuable insights to the medical community and enhance patient care both locally and globally. Through its commitment to ethical research practices and excellence, the university plays a pivotal role in shaping the future of healthcare in the region.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported