Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters

Launched by ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY · Dec 25, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how certain eye features could help doctors understand liver disease better, especially for patients who are waiting for a liver transplant. Researchers want to see if they can use information from eye tests to create a model that predicts how patients will do before and after their transplant. This study aims to improve the management of liver disease by connecting eye health with liver health.

To participate in this trial, you need to be at least 18 years old and have late-stage liver disease or cirrhosis, which is a serious scarring of the liver. You will also need to be able to complete various eye tests and provide important health information. If you join the study, you can expect to undergo eye examinations and have your liver health monitored closely. It’s important to note that people who have had other organ transplants or certain eye conditions may not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age greater than or equal to 18 years old;
• • 2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;
• • 3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;
• • 4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;
• • 5. Voluntarily follow the clinical trial protocol and sign the informed consent form.
• Exclusion Criteria:
• • 1. History of other organ transplant surgeries;
• • 2. History of intraocular laser treatment, medication injection, and surgery;
• • 3. History of high myopia, glaucoma, and retinal choroidal related eye diseases;
• • 4. History of major systemic diseases other than liver disease;
• • 5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.