Amobarbital and Cardiopulmonary Bypass

Launched by TONGJI HOSPITAL · Dec 26, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called amobarbital during heart surgery that involves a procedure known as cardiopulmonary bypass. Researchers want to understand if amobarbital can help protect the heart and improve outcomes for patients during and after surgery. This study is important because it explores how older medications can be used in new ways to enhance patient care.

To participate in this trial, you must be between 18 and 65 years old and scheduled for elective heart surgery that will last between 3 to 6 hours. Additionally, you should be in relatively good health, as determined by specific criteria. If you qualify and decide to join, you'll be asked to sign a consent form, and the study will monitor your health throughout the surgery. It’s essential to know that certain health conditions, like severe liver or kidney issues, or a history of substance abuse, may prevent you from participating. The trial is currently recruiting participants, and it aims to provide valuable insights that could improve treatment for patients undergoing heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age range: 18-65 years old, undergo elective cardiac surgery with extracorporeal circulation.
• • ASA II-III;
• • surgical duration is 3-6 hours;
• • Sign the informed consent form
• Exclusion Criteria:
• • BMI less than 18 kg/m2 or greater than 30 kg/m2;
• • Individuals with a history or potential history of drug abuse or alcohol dependence;
• • Preoperative use of sedatives or analgesics;
• • Individuals with severe liver and kidney dysfunction;
• • Individuals who are allergic or potentially allergic to barbiturates;
• • Patients with coagulation dysfunction, endocrine disorders, or other conditions that affect hemodynamic status;
• • Participated in other clinical studies in the past 3 months;
• • The researchers believe that participants who are not suitable to participate in this study.