Coffee Bioequivalence Trial

Launched by UNIVERSITY OF READING · Jan 2, 2025

Keywords

ClinConnect Summary

The Coffee Bioequivalence Trial is a research study that aims to find out if drinking coffee has the same effects on the body as taking it in tablet form. The trial will also look at how both forms of coffee affect heart health and liver function compared to people who do not drink coffee. The researchers want to see if the compounds in coffee enter the bloodstream and urine in the same way, no matter how it’s consumed.

To participate, you must be a healthy adult aged 18 to 45, and you should have a body mass index (BMI) between 18.5 and 30. If you’re eligible, you’ll visit the clinical unit three times, where you will try coffee in both forms and a coffee-free control over the course of several hours. During these visits, you’ll have your blood drawn regularly, and the next day, you'll return for a fasting blood sample. Additionally, you’ll collect your urine for 24 hours and keep track of what you eat and drink for three days. It's important to note that this study is not currently recruiting participants and has specific health criteria that might exclude you if you have certain medical conditions or are taking particular medications.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy males and pre-menopausal females (must have regular menstrual cycles)
• • Aged between 18 to 45 years
• • Body mass index (BMI) between 18.5-30 kg/m2
• Exclusion Criteria:
• • Sensitivity to coffee and caffeine
• • Food allergies relating to the test meals provided (such as gluten or lactose intolerance)
• • Current smoking and vaping use.
• • Medical history of chronic diseases (cancer, high blood pressure (hypertension), type 2 diabetes, heart attack and/or any other heart disease related diseases, gastrointestinal disorders, hyperlipidaemia, kidney or liver disease).
• • Diagnosed with anaemia
• • Prescribed any medication relating to the study outcome measures (such as blood pressure lowering, anti-inflammatories or blood thinners).
• • Drinking more than the recommended intake for alcohol (\> 14 units/week)
• • Taking any supplements (vitamins, minerals, probiotics).
• • Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study (e.g. pacemaker)
• • Planning on a weight-reducing regimen (lost \>3 kg in the last 6 months)
• • Parallel participation in another intervention study
• • Pregnancy, planning a pregnancy in the next 6 months or breastfeeding
• • NHS blood donation in the last 3 months