A Multicentric Cohort of Autoimmune Encephalitis

Launched by XUANWU HOSPITAL, BEIJING · Dec 30, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on studying autoimmune encephalitis, a condition where the body's immune system mistakenly attacks the brain. The goal is to create a group of patients with different types of this condition and track their health outcomes. Researchers will collect information about patients' medical history, blood samples, and brain scans to identify potential markers that could help in diagnosing and treating this illness more effectively. They hope to find signs that could alert doctors to changes in a patient's condition early on.

Anyone who has recently been diagnosed with autoimmune encephalitis may be eligible to participate, regardless of their age or gender. This includes patients diagnosed with "definite" or "possible" autoimmune encephalitis, as well as those with epilepsy related to this condition. Participants will need to provide consent to join the study. Although the trial is not currently recruiting, it aims to gather valuable data that could lead to better treatments and understanding of autoimmune encephalitis in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * 1. Gender and age are not limited; 2. Newly diagnosed autoimmune encephalitis according to at least one of the following three criteria:
• • 1. According to the criteria of Graus et al in 2016, diagnosed as "definite autoimmune limbic encephalitis"
• • 2. According to the criteria of Graus et al in 2016, diagnosed as "possible autoimmune encephalitis" and typical autoantibodies are detected in serum or cerebrospinal fluid
• • 3. According to the criteria of Graus et al in 2021, diagnosed as "possible or definite paraneoplastic neurological syndrome" (excluding peripheral nervous system syndrome) 3. The patient or legal representative voluntarily signed the paper informed consent form.
• • Additional inclusion criteria for patients in the epilepsy subgroup: patients diagnosed with epilepsy secondary to autoimmune encephalitis.
• Exclusion Criteria:
• • No additional exclusion criteria