Impaired Type I IFN Immunity Due to Autoantibodies or a Genetic Defect: a Prospective National Cohort

Launched by INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, FRANCE · Jan 6, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how certain genetic factors and antibodies can affect people’s immune response, especially to infections like COVID-19. Researchers have found that some individuals with severe COVID-19 disease have a genetic condition that impacts their immune system or have antibodies that hinder their ability to respond to infections. The goal of this study is to follow a group of adults who either have these antibodies or genetic issues for 1 to 4 years. By monitoring their health over time, the researchers hope to learn more about how to prevent and treat infections and autoimmune diseases in these individuals.

To participate, applicants need to be over 18 years old and have a history of either having antibodies against type I interferons (a part of the immune response) or a genetic defect affecting this response. Participants will attend annual check-ups, where they will provide blood samples and answer questions about their health. If they experience any health issues, such as infections or new autoimmune diseases, they will have additional visits to monitor their condition. Participants will also be offered vaccines for COVID-19 and influenza. Overall, this study aims to gain valuable insights into the immune system and improve care for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>18 years
• • History of carrying 1) auto-Abs against type I IFNs or 2) IEI impairing the response to, or the production of, type I IFNs (IFN-I-IEI)
• • Affiliated to social security
• • Written informed consent
• Exclusion Criteria:
• • Participation to an interventional clinical trial on a pharmacological treatment
• • Clinical condition leading to life expectancy less than 1 year
• • Subject to a legal protection measure (safeguard of justice, curatorship, tutorship)
• • Individuals deprived of freedom