Effects of Low-Sodium Salt on Death, HF Hospitalization/ Emergency Department Visits and Quality of Life in HF Patients

Launched by HEART HEALTH RESEARCH CENTER · Jan 1, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether using a low-sodium salt substitute can help people with heart failure. The researchers want to see if this salt can lower the chances of dying, being readmitted to the hospital, or visiting the emergency room. They also hope it will make patients feel better overall.

To be eligible for the study, participants need to be between 18 and 75 years old, have been hospitalized for heart failure in the past year, and have certain heart function measurements. It’s important that participants have a stable condition and live with someone who helps them with meals. They will need to agree to use the low-sodium salt and provide consent to participate. If you or someone you know is interested in joining, it’s a chance to contribute to important research that could improve life for those with heart failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged between 18 and 75 years;
• • 2. Hospitalized due to heart failure in the past year;
• • 3. NYHA functional class II-III;
• • 4. Echocardiographic evidence of LVEF \< 40% within the past 6 months;
• • 5. Receiving guideline-directed medical therapy for heart failure;
• • 6. Stable heart failure status, defined as heart failure stability for more than 4 weeks, with no increase in diuretic dose within the past 4 weeks;
• • 7. Having a primary caregiver and frequently dining together at home;
• • 8. Consuming commercially processed food no more than once a week;
• • 9. Providing written informed consent.
• Exclusion Criteria:
• • 1. End-stage heart failure;
• • 2. Hospitalization due to cardiovascular causes within the past month;
• • 3. Uncorrected hyponatremia (Na \< 130 mmol/L);
• • 4. Dialysis-dependent patients, or eGFR \< 20 mL/min/1.73m²;
• • 5. Uncontrolled hyperglycemia, with fasting blood glucose \> 16 mmol/L;
• • 6. Malignant cancer patients with a life expectancy of less than 1 year;
• • 7. Conditions that, in the investigator's opinion, may interfere with adherence to the protocol, such as habitual reliance on takeout meals or dining at company cafeterias;
• • 8. Planned hospitalization during the study period;
• • 9. Unexplained weight loss greater than 5 kg in the past year;
• • 10. The subject or family members have concerns about using the salt substitute in this study, or are planning for pregnancy, pregnant, or breastfeeding;
• • 11. Another family member is already participating in this study;
• • 12. The subject or family members are participating in other interventional clinical trials.