AI Models for Cerebral Aneurysms Segmentation, Detection and Stability Prediction

Launched by SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE'S HOSPITAL · Jan 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how artificial intelligence (AI) can help doctors detect and assess the risk of unruptured cerebral aneurysms, which are bulges in blood vessels in the brain that can potentially rupture and cause serious health problems. The goal is to improve the accuracy of diagnosing these aneurysms and to identify which ones are at higher risk of rupturing, so that patients can receive the appropriate care without unnecessary treatments. The researchers will use non-invasive imaging techniques, like MRI and CT scans, to gather data and analyze it over time to better predict outcomes for these aneurysms.

To participate in this trial, individuals must be at least 18 years old and have either been diagnosed with or shown signs of a cerebral aneurysm. They should also be undergoing specific imaging tests like a head MRI or CT scan. Participants will have the opportunity to help develop new AI technology that could benefit future patients by improving the way doctors diagnose and manage cerebral aneurysms. It's important to note that certain health conditions and previous treatments may exclude individuals from participating in the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years;
• • 2. Preliminary diagnosis or symptoms indicating the presence or potential presence of a cerebral aneurysm;
• • 3. Undergoing a non-contrast head MRA or contrast-enhanced head/neck CTA;
• • 4. The patient or their legal representative is able and willing to sign an informed consent form.
• Exclusion Criteria:
• • 1. Other intracranial vascular diseases: moyamoya disease, arteriovenous malformations, arteriovenous fistulas, arterial occlusions, and arterial dissections;
• • 2. History of intracranial arterial interventions: stent placement, partial aneurysm coil treatment, etc.;
• • 3. Severe allergy to contrast agents or absolute contraindications to iodine-based contrast agents;
• • 4. Renal insufficiency with elevated serum creatinine (greater than twice the upper normal limit);
• • 5. MRI contraindications: pacemakers, claustrophobia, etc.;
• • 6. Diseases or conditions that affect the quality of CTA/MRA images;
• • 7. Inability to complete the study due to psychiatric disorders, cognitive, or emotional disturbances.
• • Note: The CTA sub-study does not include exclusion criterion 5; the MRA sub-study does not include exclusion criteria 3 and 4.