Supplementing Neuro-Energy to Aid Cognition

Launched by UNIVERSITY OF PENNSYLVANIA · Jan 6, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Supplementing Neuro-Energy to Aid Cognition," is focused on understanding how brain energy is affected as we age, particularly in people with Alzheimer’s disease and related dementias. The researchers plan to use advanced imaging techniques to look at how well the brain is getting the energy it needs. This is important because our brains require a steady supply of glucose and oxygen to function properly, and changes in this energy supply can impact cognitive health.

To participate in this study, individuals aged 21 to 80 years old may be eligible if they are either healthy or have been diagnosed with mild cognitive impairment or mild-to-moderate dementia. Healthy participants should have a Body Mass Index (BMI) between 18.5 and 30, while those with Alzheimer's must show certain biomarkers through imaging or tests. However, there are some exclusions, such as individuals with certain medical devices, neurological diseases, or those who are pregnant or breastfeeding. Participants can expect non-invasive imaging procedures that will help researchers learn more about brain health and energy needs, contributing to better understanding and possibly new treatments for dementia in the future.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria - Healthy Participants: Males and females, Age 21 - 80 years, BMI of 18.5-30
• • Inclusion Criteria - Alzheimer's Disease Participants: Positive amyloid and tau biomarkers (as noted by PET imaging, cerebrospinal fluid or blood), Mild cognitive impairment or mild-to-moderate dementia, BMI of 18.5-30
• • Exclusion Criteria: Contraindications to MRI (claustrophobia, metal implants, pacemakers, etc.), Pregnant or breastfeeding women, Neurological disease (healthy participants only), Mental illness, Overt cardio- or neurovascular disease, Recent participation in any procedure(s) involving radioactive agents