Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?

Launched by MEMORIAL UNIVERSITY OF NEWFOUNDLAND · Jan 5, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring the best treatment approach for people who are very overweight and suffering from severe knee arthritis. Specifically, it aims to find out whether having weight loss surgery (called sleeve gastrectomy) before knee replacement surgery leads to better results than having knee replacement first. By comparing the two groups of participants—one group will have weight loss surgery first and the other will have knee replacement first—the researchers hope to learn which order of procedures helps improve quality of life and if there are differences in complications.

To participate in this study, individuals need to be between the ages of 65 and 74, have a body mass index (BMI) of 35 or higher, and be on the waiting list for both knee replacement and weight loss surgery. Participants will be randomly assigned to one of the two treatment orders and will fill out questionnaires to assess their quality of life before and after each procedure. The study is not yet recruiting participants, and it aims to gather important information that could help improve treatment strategies for those facing these health challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI \> or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy
• Exclusion Criteria:
• • a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class \> 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.