Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
Launched by UNIVERSITY OF SOUTH CAROLINA · Jan 6, 2025
Trial Information
Current as of July 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking to improve an online exercise program designed for adults who have had total knee replacements. The goal is to find out which extra features added to the program help participants become more physically active. Researchers will track changes in physical activity levels, pain, and physical function at 6 and 12 months after joining the study.
To be eligible for this trial, participants should be between 65 and 74 years old, have had knee replacement surgery at least a year ago, and only be doing less than an hour of moderate exercise each week. They also need to have a device with internet access and be comfortable reading English. Participants will complete four online assessments and may receive different additional support options during the study. It's important to note that individuals with certain health issues or those currently in physical therapy may not qualify. If you're interested in improving your physical activity after knee replacement, this study could be a great opportunity!
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago
- • have a computer, tablet, or smartphone with active internet access
- • self-report engaging in less than 60 minutes/week of moderate-intensity physical activity
- • be English-speaking and able to read consent and study materials written in English
- • be willing to complete the 4 remote assessments, including physical activity monitoring
- • be willing to be randomized to receive 0-4 supplemental intervention components.
- Exclusion Criteria:
- • any contraindications to physical activity (e.g., chest pain)
- • have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)
- • have a mobility limiting comorbidity unrelated to knee replacement
- • live outside of the continental U.S
- • do not currently have a physician or orthopedic surgeon whom they see regularly
- • are currently participating in physical therapy (for knee)
- • are participating in a structured weight loss or physical activity program
- • unable to provide proof of knee replacement surgery
- • have a BMI \>40kg/m2
- • score \>30 on PROMIS cognitive function
About University Of South Carolina
The University of South Carolina (USC) is a leading research institution dedicated to advancing healthcare through innovative clinical trials and studies. With a commitment to excellence in research and education, USC leverages its multidisciplinary expertise and state-of-the-art facilities to conduct rigorous clinical investigations aimed at improving patient outcomes and addressing pressing health challenges. Collaborating with a diverse network of healthcare professionals, researchers, and community partners, USC fosters an environment of discovery and translation, ensuring that findings from clinical trials contribute significantly to the advancement of medical science and evidence-based practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Columbia, South Carolina, United States
Patients applied
Trial Officials
Christine Pellegrini, PhD
Principal Investigator
University of South Carolina
Jessica Unick, PhD
Principal Investigator
The Miriam Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported