Exogenous Ketosis and Muscle Protein Synthesis During Exercise Recovery

Launched by MCGILL UNIVERSITY · Jan 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a special type of supplement called ketone bodies can affect muscle recovery after exercise, specifically resistance training like weightlifting. Researchers want to see if taking ketone supplements alone or along with a protein shake (25 grams of whey protein) can help increase the rate at which muscles rebuild and grow after a workout. The goal is to find out if these ketone supplements can make the protein more effective in helping muscles recover, which could be beneficial for anyone looking to improve their fitness and strength.

To participate in this study, you need to be a healthy adult between 18 and 40 years old, and you should have been doing some weightlifting at least once a week for the last two months. You also need to have a stable diet and lifestyle, meaning you haven't made big changes to your eating or exercise habits in the last three months. Participants will need to avoid alcohol for two days before their testing day and be willing to follow the study's guidelines. If you're interested and meet these criteria, this trial could be a great opportunity to contribute to important research on muscle recovery!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy adult female or male participants who are 18-40 years of age (inclusive) BMI \>18.5 and \<30.0 kg/m2
• • Moderately active (i.e., ≥ 1 session of lower-body weightlifting /week for the previous 2 months).
• • Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study.
• • Be willing to entirely avoid alcohol consumption 48hr prior to the experimental test day.
• • Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures.
• Exclusion Criteria:
• • Females who are lactating or pregnant
• • Females using third-generation oral contraceptives (including: Desogen®, Ortho-Cept, Ortho-Cyclen, Ortho Tri-Cyclen) as these are known to affect protein metabolism in females.
• • Individuals with metabolic disorders including: Type I or Type II diabetes
• • Individuals with a history of thrombosis / cardiovascular disease
• • Individuals who use of anticoagulants
• • Individuals with musculoskeletal / orthopedic disorders
• • Individuals with knee injuries (i.e., ACL injuries).
• • Individuals who have used tobacco products within the last 6 months
• • Individuals with a history of neuromuscular problems
• • Chronic usage of medications known to modulate skeletal muscle metabolism (i.e. corticosteroids, hormone replacement therapy (HRT), and over-the-counter supplements including creatine monohydrate) in the last 6 months.
• • Individuals with allergies to milk proteins (whey or casein).
• • Individuals with lactose intolerance
• • Individuals with Phenylketonuria (PKU)
• • Previous participation in amino acid tracer studies.
• • Adherence to a vegetarian or vegan diet
• • Current use of ketone supplements or adherence to a ketogenic diet
• • Individuals who train more than ≥ 5 sessions of lower-body weightlifting /week for the previous 4 months